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Serum FAM132A/Adipolin correlates with endothelial dysfunction in children with obesity
1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Pediatric Research
|June 23, 2026
Summary
Serum FAM132A (Adipolin) is elevated in obese children and linked to vascular injury markers. This suggests FAM132A may serve as an early biomarker for pediatric cardiovascular risk.
Area of Science:
- Pediatric endocrinology and cardiovascular research.
- Biomarker discovery for metabolic and vascular diseases.
Background:
- Early identification of cardiovascular risk in children is crucial.
- Biomarkers are needed to link adiposity with vascular injury in pediatric populations.
Purpose of the Study:
- To investigate the association between serum FAM132A (Adipolin) and markers of endothelial dysfunction in Chinese children with obesity.
- To determine if FAM132A is an independent predictor of vascular injury in this cohort.
Main Methods:
- A case-control study involving 82 obese children and 50 normal-weight controls.
- Measurement of serum FAM132A, adiponectin, leptin, and endothelial markers (VCAM-1, E-selectin, ESM-1) using ELISA.
- Multiple linear regression analysis adjusted for relevant covariates.
Main Results:
- Serum FAM132A levels were significantly higher in children with obesity compared to controls.
- FAM132A positively correlated with BMI, waist-hip ratio, ALT, and endothelial markers.
- FAM132A independently predicted VCAM-1, E-selectin, and ESM-1, independent of insulin resistance and other adipokines.
Conclusions:
- Serum FAM132A is paradoxically elevated in pediatric obesity.
- FAM132A is independently associated with endothelial activation, suggesting a role in early metabolic stress.
- FAM132A shows potential as an early biomarker for vascular injury in children, warranting further validation.
