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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...

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Related Experiment Video

Updated: Jun 25, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
08:38

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells

Published on: March 3, 2015

Mapping and engineering the human cell-cell interactome.

Dino Di Carlo1, Leonardo Morsut2, Megan L McCain2

  • 1University of California, Los Angeles, Los Angeles, CA, USA. dicarlo@ucla.edu.

Nature Biotechnology
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Scientists propose mapping the human cell-cell interactome to understand how cells communicate. This initiative aims to create a functional atlas for discovering new therapies by studying cell interactions.

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Area of Science:

  • Cell biology
  • Systems biology
  • Genomics

Background:

  • Single-cell transcriptomics and spatial profiling have advanced understanding of molecular states within tissues.
  • A significant knowledge gap exists regarding how cells influence each other within their microenvironment.
  • Understanding cell-cell communication is crucial for tissue-level function.

Purpose of the Study:

  • To propose an initiative for mapping and engineering the human cell-cell interactome.
  • To create a functional atlas detailing communication between major human cell types.
  • To leverage recent technological innovations to achieve this vision.

Main Methods:

  • Proposing the 'Billion Cell×Cell Project' as a first moonshot initiative.
  • Systematically characterizing the outcomes of defined cell-cell dyads.
  • Utilizing diverse cell types and experimental conditions.

Main Results:

  • The proposed initiative will generate a comprehensive map of cell-cell interactions.
  • It will provide insights into the functional consequences of cellular communication.
  • The project aims to unlock new avenues for therapeutic discovery.

Conclusions:

  • Mapping the human cell-cell interactome is an achievable goal with current and emerging technologies.
  • This initiative promises to deepen our understanding of cellular communication.
  • Collaboration is called upon to build the necessary tools, datasets, and models.