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Published on: July 30, 2009

Feasibility of remimazolam rescue sedation for neonatal MRI: a case report

Di Wu1, Lin Chen1, Jing Cheng1

  • 1Department of Anesthesiology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.

BMC Anesthesiology
|June 24, 2026
PubMed
Abstract

Insights

Remimazolam, a sedative, was successfully used for neonatal MRI sedation in a single case. This offers a potential rescue option for challenging neonatal imaging procedures requiring sedation.

Area of Science:

  • Neonatal imaging
  • Pediatric anesthesiology
  • Pharmacology

Background:

  • Neonatal imaging requires sedation to reduce motion artifacts.
  • Sedation in neonates presents unique challenges due to physiological differences.
  • Limited evidence exists for remimazolam's use in neonatal MRI.

Purpose of the Study:

  • To report the first use of remimazolam for neonatal MRI sedation.
  • To assess the efficacy and safety of remimazolam in a neonatal case.

Main Methods:

  • Case report of an early-term neonate (37 ⁴⁄₇ weeks GA, 2.9 kg).
  • Intravenous remimazolam (0.1 mg/kg) administered after other methods failed.
  • Monitoring of hemodynamic and respiratory stability during MRI.

Main Results:

  • Successful sedation achieved within 1 minute of remimazolam administration.
  • 17-minute MRI completed with preserved cardiorespiratory function.
  • Remimazolam demonstrated rapid onset and stability.

Conclusions:

  • Remimazolam shows potential as a rescue sedative for neonatal MRI.
  • Further multicenter studies are needed to confirm safety and efficacy.
  • Investigating remimazolam's role in clinical practice is warranted.
Keywords:
Magnetic resonance imagingNeonatesPediatric anesthesiaRemimazolamSedation

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