Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Evaluation of the Storage Stability of Extracellular Vesicles

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.

Xian Huang^1,2, Qiujie Li², Guofang Tao³

¹College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China.

|June 24, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Blue:red LED ratios coordinate pigment accumulation and vacuolar pH to reshape petal color and VOC profiles in Rosa hybrida 'Juicy Terrazza'.

BMC plant biology·2026

Same author

Effects of different dual-task trainings on gait and cortical activation during obstacle crossing in stroke patients: a randomized controlled trial.

Frontiers in physiology·2026

Same author

p53 overrides <i>METTL5</i> loss-induced tumor suppression via mitochondrial respiration.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

A spatially confined "double-key lock" smart DNA hydrogel for dynamic detection of MicroRNA in cells.

Chemical science·2026

Same author

Trained immunity-primed DLL3-targeted CAR macrophages for the eradication of small cell lung cancer.

Journal of advanced research·2026

Same author

A self-powered chloroplast-driven nanophotosystem for treating skin photoaging through rejuvenating mitochondria and revitalizing senescent fibroblasts.

Journal of nanobiotechnology·2026

Extracellular vesicles (EVs) show promise for anti-aging therapies by addressing key aging hallmarks like inflammation and mitochondrial dysfunction. This review details EV mechanisms, delivery, and challenges for clinical translation.

Area of Science:

Gerontology and Regenerative Medicine
Nanomedicine and Drug Delivery
Molecular Biology and Aging

Background:

Aging is characterized by complex, interconnected hallmarks including chronic inflammation, mitochondrial dysfunction, and altered intercellular communication.
Extracellular vesicles (EVs) are nanoscale vesicles with therapeutic potential for regenerative and anti-aging applications due to their cargo-carrying capacity.

Purpose of the Study:

To systematically review the multifaceted anti-aging mechanisms of EVs.
To integrate EV targeting biology, cellular entry, and delivery engineering for therapeutic development.
To provide a comprehensive framework connecting molecular mechanisms with clinical translation challenges and solutions.

Main Methods:

Systematic review of literature on EV mechanisms in aging.

Keywords:

aging clinical translation extracellular vesicles targeted delivery

More Related Videos

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

Related Experiment Videos

Last Updated: Jun 25, 2026

Evaluation of the Storage Stability of Extracellular Vesicles

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

Analysis of EV targeting strategies, biodistribution, and cellular entry pathways.

Evaluation of technical bottlenecks and emerging solutions for EV-based therapeutics.

Main Results:

EVs suppress senescence-associated secretory phenotype (SASP), modulate the immune microenvironment, restore mitochondrial function, and aid DNA repair.
EVs facilitate epigenetic modulation, proteostasis recovery, regenerative signaling, and cross-organ rejuvenation.
Engineering strategies and advanced delivery systems are emerging to overcome challenges like EV heterogeneity and delivery efficiency.

Conclusions:

EVs offer a versatile platform for next-generation anti-aging nanotherapeutics.
Bridging fundamental biology, nanomedicine, and clinical translation is crucial for developing effective EV therapies.
Standardized quality control and scalable manufacturing are key to realizing the clinical potential of EV-based anti-aging treatments.