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Updated: Jun 25, 2026
06:20
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential
Chih-Chiang Chang1, Yangguang Ma2, Minglei Kang3,4
1Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.
Journal of Applied Clinical Medical Physics
|June 24, 2026
Summary
Ultra-high dose rate radiotherapy, known as FLASH radiotherapy, may reduce side effects. However, research shows unexpected toxicities, emphasizing the need for precision and safety in radiation oncology.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- FLASH radiotherapy offers potential for reduced normal tissue toxicity and maintained tumor control.
- Preclinical and early clinical data indicate biological and technical uncertainties associated with FLASH radiotherapy.
Purpose of the Study:
- To review preclinical and veterinary studies on FLASH radiotherapy.
- To highlight unexpected toxicities observed in FLASH radiotherapy.
- To emphasize the continued importance of precision and safety principles in radiotherapy.
Main Methods:
- Review of preclinical studies.
- Analysis of veterinary studies.
- Evaluation of early clinical evidence.
Main Results:
- Unexpected toxicities have been observed with FLASH radiotherapy.
- Biological and technical uncertainties require further investigation.
- Fundamental principles of radiotherapy remain critical.
Conclusions:
- FLASH radiotherapy requires careful consideration of potential risks.
- Precision and safety, including conformal treatment and ALARA principles, are paramount.
- Further research is needed to address uncertainties in FLASH radiotherapy.
Keywords:
ALARAFLASH radiotherapydosimetrynormal tissue sparingproton therapytoxicitytreatment planningultrahigh dose rateMore Related Videos
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