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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential
Chih-Chiang Chang1, Yangguang Ma2, Minglei Kang3,4
1Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.
None:
FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in radiotherapy-particularly conformal treatment and ALARA-remain crucial.
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