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Updated: Jun 25, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Synthesis, characterization, crystal structures and urease inhibitory activity of new acylhydrazone complex materials
1School of Information Science and Engineering, Shenyang Ligong University, Shenyang 110159, P. R. China.
Abstract:
In this work, four new oxidovanadium(V) complexes with the general formula [VOLL'] were prepared. L is the dianionic form of 2-hydroxy-5-methyl-N'-(3-methylbenzylidene)benzohydrazide (H2L1) for complexes 1 and 2, and 2-hydroxy-4-methoxy-N'-(3-methylbenzylidene)benzohydrazide (H2L2) for complexes 3 and 4. L' is the deprotonated form of methyl maltol (HLa) for complexes 1 and 3, and ethyl maltol (HLb) for complexes 2 and 4. The structural features of the complexes were assigned using the single crystal X-ray diffraction and other physicochemical techniques. The V atoms in the complexes are in octahedral coordination. Inhibitory activities of the acylhydrazones and complexes were evaluated on Helicobacter pylori urease. All the complexes show effective activity with IC50 values of 15.3-27.2 μmol L-1.
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