Related Experiment Video
Updated: Jun 25, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study
Yingtao Wang1,2,3, Shaoxin Tao1,2,3, Qiujia Wang1,2,3
1Department of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Background:
Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remain incompletely understood.
Objectives:
To identify clinical and modifiable factors associated with relapse and disability in MOGAD.
Methods:
In this ambispective multicentre cohort study using data from the Chinese Neuroimmunological Diseases (NIDBase) cohort (21 Chinese centres; January 2020-December 2024), 173 MOGAD patients with ≥ 12-month follow-up were analysed. Time to first relapse and time to disability, defined as Expanded Disability Status Scale (EDSS) score ≥ 2 confirmed outside acute relapse periods, were analysed using Cox regression. Nonlinear associations were assessed using restricted cubic splines.
Results:
Older age at onset and smoking history were associated with increased disability risk. Smoking was also associated with relapse risk, although its association was attenuated and no longer statistically significant after adjustment. BMI showed nonlinear associations with both relapse and disability outcomes.
Conclusions:
In MOGAD, older age at onset, smoking, and BMI may influence prognosis. These findings support further investigation of modifiable lifestyle and metabolic factors in prognostic stratification.
Related Concept Videos
Factors Affecting Illness
For instance, risk factors are connected to illness, disability,...
Psychological and Sociocultural Causes of Schizophrenia
Classification of Illness
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Multiple Sclerosis l: Introduction
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
