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Updated: Jun 25, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
Published on: May 22, 2026
Chemotherapy neurotoxicity and aging: Uncovering shared central nervous system pathologies and potential
Maria Sacconi Nunez1, Erin M Gibson1
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
None:
Advances in cancer therapies have significantly improved survival rates, but many survivors face persistent cognitive impairments collectively termed chemotherapy-related cognitive impairment (CRCI). Symptoms such as memory deficits, reduced attention, impaired executive function, and slowed information processing can profoundly affect quality of life, often persisting for years or even decades. The cellular and molecular mechanisms underlying CRCI remain poorly understood, but accumulating evidence suggests that cancer therapy accelerates aging-like processes in the brain. This review positions CRCI as a model of induced aging and neurodegeneration, emphasizing shared central nervous system (CNS) pathologies with aging such as neuroinflammation, blood-brain barrier disruptions, reduced neurogenesis, hypomyelination, and cellular senescence, providing a novel framework for investigating CRCI. This review highlights the parallels between CRCI and aging, proposing that insights from aging research can inform the development of targeted interventions to mitigate CNS-related CRCI symptoms. Addressing these shared mechanisms may lead to innovative therapies that improve cognitive outcomes and enhance the quality of life for cancer survivors.
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