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Cognitive Dysfunction Associated With Cellular Immunotherapy For Cancer.

Home
Cognitive Dysfunction Associated With Cellular Immunotherapy For Cancer.

Related Experiment Video

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Cognitive dysfunction associated with cellular immunotherapy for cancer.

Anna G Hauswirth¹, Michael W Parsons², Jorg Dietrich¹

¹Department of Neurology, Division of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Neuro-Oncology Advances

|June 24, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

T-cell engaging immunotherapies like CAR-T cells show promise against cancer but can cause neurotoxicity. Acute cognitive effects are clearer, but long-term impacts of these cancer treatments require further study.

Keywords:

CAR-T ICANS cognition cognitive function immunotherapy

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Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

Area of Science:

Oncology
Immunology
Neuroscience

Background:

Immunotherapies, including T cell engagers (TCEs) and chimeric antigen receptor T-cell therapies (CAR-T), harness the immune system to combat hematologic and solid malignancies.
While effective, these therapies can induce significant systemic and neurologic toxicities, notably cognitive dysfunction.

Purpose of the Study:

To review the current and emerging literature on the cognitive effects of T-cell engaging immunotherapies.
To examine acute, subacute, and potential long-term cognitive outcomes associated with CAR-T cells and similar therapies.

Main Methods:

Literature review of existing and emerging research.
Analysis of studies investigating neurotoxicity and cognitive outcomes following T-cell based immunotherapies.

Main Results:

Acute cognitive effects, including immune effector cell-associated neurotoxicity syndrome (ICANS), are increasingly understood.
Data regarding long-term subjective and objective cognitive outcomes after T-cell immunotherapies remains mixed and requires further investigation.

Conclusions:

T-cell engaging immunotherapies offer durable responses but necessitate careful monitoring for neurotoxicity.
Additional research is crucial to fully understand and manage the long-term cognitive sequelae as these cancer therapies gain wider application.