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Closing the loop in nanotheranostics: from 124I separation to intrinsically radiolabeled platinum nanoparticles for
Sanchita Ghosh1,2, Rajwardhan N Ambade1, Ramu Ram1
1Radiopharmaceuticals Division, Bhabha Atomic Research Centre Trombay Mumbai 400085 India rubelc@barc.gov.in.
Abstract:
Closing the loop in nanotheranostics, we integrate radionuclide production with functional nanomedicine through mesoporous alumina based radiochemical separation of no-carrier-added (NCA) 124I and its direct incorporation into protein functionalized platinum nanoparticles. The intrinsically radiolabeled [124I]I-Pt@GA shows high labeling efficiency, excellent stability, quantitative PET imaging, and effective photothermal cancer cell ablation.
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