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Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
Mycobacterium colombiense isolation among people living with human immunodeficiency virus: a case series
Manuel Paz-Infanzon1, Karla Paola Cuellar-Calderón1, Samantha Flores-Treviño1
1Department of Infectious Diseases, University Hospital "Dr. José Eleuterio González", Autonomous University of Nuevo Leon, Monterrey, México.
Abstract:
Mycobacterium colombiense is a seldom reported non-tuberculous mycobacteria causing infections mostly in immunosuppressed patients. Thus, we present the findings of three M. colombiense isolation cases from a third-level hospital in Monterrey, Mexico, during 2020-2024. Mycobacterial identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and Anyplex™ MTB/NTM Real-time Detection. Patients were people living with Human Immunodeficiency Virus (PLHIV), with pneumonia and lymphadenopathy. Patients had high HIV viral loads and low CD4 counts (21-103 cells/mm3). None of the cases had specific Mycobacterium avium complex (MAC) treatment, and all of them showed clinical improvement. Current non-tuberculous mycobacteria discrimination tests may not effectively diagnose significant pathogens like M. colombiense, potentially leading to delays in treatment and negatively impacting patient outcomes.
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