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Related Experiment Video

Updated: Jun 25, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
07:20

Inducement and Evaluation of a Murine Model of Experimental Myopia

Published on: January 22, 2019

Effect of Variation in Extended Depth-Of-Focus Design on Myopia Control and Visual Function in Japanese Children.

Sayuri Ninomiya1, Shizuka Koh, Sachiyo Ueshima

  • 1Itami Central Eye Clinic (S.N., S.U.), Hyogo, Japan; Department of Innovative Visual Science (S.K.), The University of Osaka Graduate School of Medicine, Osaka, Japan; and Department of Ophthalmology (S.K., K.N.), The University of Osaka Graduate School of Medicine, Osaka, Japan.

Eye & Contact Lens
|June 24, 2026
PubMed
Summary

Mid-depth extended depth-of-focus (EDOF) soft contact lenses effectively control myopia progression in children. Low-depth EDOF lenses did not show significant benefits over standard lenses for myopia control.

Keywords:
Extended depth-of-focusJapanese childrenMyopia controlOptical designSoft contact lensesVisual function

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Last Updated: Jun 25, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
07:20

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Published on: January 22, 2019

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
07:06

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

Area of Science:

  • Ophthalmology
  • Pediatric Optometry
  • Myopia Control Research

Background:

  • Myopia is a growing public health concern globally.
  • Effective myopia control strategies are crucial for preventing vision impairment in children.
  • Extended Depth-of-Focus (EDOF) contact lenses offer a potential new avenue for myopia management.

Purpose of the Study:

  • To assess the efficacy of EDOF soft contact lenses with varying optical designs in controlling myopia progression.
  • To evaluate the impact of these EDOF lenses on visual function in Japanese children.
  • To compare Mid-EDOF and Low-EDOF lens performance against single-vision lenses.

Main Methods:

  • A 12-month, multicenter, double-masked, randomized controlled trial.
  • Involved 60 Japanese children (aged 6-12 years).
  • Compared Mid-EDOF (+1.50 D), Low-EDOF (+0.75 D), and single-vision contact lenses; measured axial length and refractive error.

Main Results:

  • Mid-EDOF lenses significantly reduced axial elongation (49%) and SE progression (59%) versus single-vision lenses (P<0.01).
  • Low-EDOF lenses showed no significant effect on myopia progression.
  • Mid-EDOF lenses led to minor decreases in contrast sensitivity and increases in higher-order aberrations (HOAs), with comparable subjective visual quality.

Conclusions:

  • Mid-EDOF soft contact lenses demonstrate significant efficacy in suppressing myopia progression in children.
  • The optical profile of EDOF lenses is critical for myopia control effectiveness.
  • Low-EDOF lenses were not superior to single-vision lenses, highlighting the importance of lens design in myopia management.