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Published on: March 30, 2014
Treatment failure in adolescents and young people living with HIV: a cohort study
Camila Moraes Garollo Piran1,2, Alana Vitória Escritori Cargnin1, Mariana Martire Mori1
1Universidade Estadual de Maringá. Maringá, Paraná, Brazil.
Objectives:
to analyze factors associated with poor adherence and loss to follow-up among adolescents and young people living with HIV.
Methods:
ambidirectional cohort study of 512 adolescents and young people with HIV receiving treatment at a specialized service in northwestern Paraná, Brazil. Poisson regression with robust variance was performed.
Results:
having a sexual partner, time between diagnosis and antiretroviral therapy initiation, and missed appointments were negatively associated with poor adherence. Age group of 20-24 years was positively associated with adherence. Drug use, an antiretroviral therapy regimen consisting of lamivudine+tenofovir+efavirenz, last unsuppressed viral load result before the outcome, time between diagnosis and antiretroviral therapy, and missed appointments were associated with loss to follow-up. Alcohol use, the first unsuppressed viral load test, and the last undetectable viral load test were positively associated.
Conclusions:
the various determinants involved in illness and treatment among adolescents and young people living with HIV were reiterated.
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