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Related Experiment Video

Updated: Jun 25, 2026

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Point-of-Care Ultrasound M-Mode Analysis Using M.mode.ify: An External Validation Study for E-point Septal Separation

David Crockett1, Elijah Wyatt2, Benjamin C Smith2

  • 1Department of Emergency Medicine, University of Utah, Salt Lake City, Utah, USA.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

M.mode.ify software accurately measures E-point septal separation (EPSS) from video clips retrospectively. This tool enhances echocardiography analysis by enabling post-acquisition M-mode parameter measurements.

Keywords:
EPSSM‐modepoint‐of‐care ultrasound

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Area of Science:

  • Cardiovascular Imaging
  • Medical Ultrasound Technology
  • Echocardiography Analysis

Background:

  • M-mode ultrasound offers high temporal resolution for precise measurement of dynamic cardiac structures.
  • Traditional M-mode imaging is restricted to real-time acquisition, limiting retrospective analysis.
  • M.mode.ify is a new software tool designed to generate M-mode tracings from video data for post-acquisition analysis.

Purpose of the Study:

  • To evaluate the accuracy and reliability of the M.mode.ify software.
  • To assess M.mode.ify's performance in measuring E-point septal separation (EPSS), a critical echocardiographic parameter.

Main Methods:

  • Retrospective analysis of 41 cardiac ultrasound studies with available M-mode EPSS and PLAX video clips.
  • Two blinded reviewers independently measured EPSS using M.mode.ify, with standard M-mode serving as the reference.
  • Inter-rater reliability and agreement with standard M-mode were assessed using Pearson correlation and absolute error calculations.

Main Results:

  • Strong inter-rater correlation (r=0.90) was observed for M.mode.ify measurements.
  • Excellent agreement (r=0.92) was found between M.mode.ify and standard M-mode EPSS measurements.
  • The mean absolute error for M.mode.ify measurements was 2.38 mm (SD 1.71 mm).

Conclusions:

  • M.mode.ify demonstrates high accuracy and reliability for retrospective EPSS measurement.
  • The software facilitates post hoc analysis of M-mode parameters, potentially increasing the value of existing ultrasound data.
  • M.mode.ify offers a valuable tool for expanding the applications of echocardiographic video analysis.