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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

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Related Experiment Video

Updated: Jun 25, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Risk Factors for Persistent Cranial Defects After Open Cranial Vault Remodeling for Sagittal Synostosis.

Jared H Chung1, Emily Dunbar2, Amanda Hendrix2

  • 1University of Virginia School of Medicine.

The Journal of Craniofacial Surgery
|June 24, 2026
PubMed
Summary

Secondary cranioplasty for persistent cranial defects after sagittal synostosis surgery occurred in 8.6% of patients. Longer procedure times showed a slight association, but no definitive predictors were identified, suggesting multifactorial causes.

Keywords:
Cranial defectscranial vault remodelingcraniectomysagittal synostosissecondary cranioplasty

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Area of Science:

  • Neurosurgery
  • Pediatric Plastic Surgery
  • Craniofacial Surgery

Background:

  • Open cranial vault remodeling is standard for sagittal synostosis.
  • Predictors for persistent cranial defects needing secondary cranioplasty are not well-defined.
  • Identifying these predictors can improve surgical planning and patient monitoring.

Purpose of the Study:

  • To identify predictors of persistent cranial defects requiring secondary cranioplasty after open cranial vault remodeling for nonsyndromic sagittal synostosis.

Main Methods:

  • Retrospective review of 93 patients (2007-2023) undergoing open cranial vault remodeling.
  • Primary outcome: secondary cranioplasty for calvarial defects.
  • Statistical analysis included logistic regression and time-to-event analyses.

Main Results:

  • Secondary cranioplasty was performed in 8.6% of patients.
  • Procedure time showed a weak association in multivariable analysis (OR 1.76), but this was not consistent in sensitivity analyses.
  • Age at surgery, bifrontal craniectomy, and craniectomy width were not significant predictors.

Conclusions:

  • Approximately 9% of patients required secondary cranioplasty.
  • No definitive predictors for secondary cranioplasty were identified.
  • The need for secondary cranioplasty is likely multifactorial, influenced by surgical complexity rather than specific patient or procedural variables.