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Flawed translation triggers oncogenic B-T cell communication
Seren Baygün1,2, Marc Schmidt-Supprian1,2
1Institute of Experimental Hematology, Center for Translational Cancer Research, School of Medicine and Health, Technical University of Munich , Munich, Germany.
Abstract:
B-T cell cross talk is safeguarded by central and peripheral tolerance and cell-intrinsic checkpoints. In this issue of JEM, Lin et al. (https://doi.org/10.1084/jem.20251968) show that altered translation in early germinal center B cells triggers a vicious cycle of aberrant B-T cell interactions culminating in lymphomagenesis.
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