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No Association of Prior Administration of Selected Vaccines with Lymphoma Prognosis

George A Cholack¹, Verena Hinder², Raphael Mwangi²

¹Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education, Rochester, Minnesota.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

|June 24, 2026

Abstract

Background:

Although some vaccines seem to be associated with a lower risk of lymphoma, their impact on outcomes is largely unknown.

Methods:

Data from a large prospective lymphoma cohort study were utilized to estimate associations of self-reported history of vaccination against hepatitis A, hepatitis B, influenza, and yellow fever with event-free survival (EFS) and overall survival (OS) using Cox proportional hazard models.

Results:

None of the vaccines were associated with EFS [hazard ratio (HR) 0.77-1] or OS (HRs 0.96-1.04). Similarly, there were no significant associations between the vaccines and outcomes for each lymphoma subtype.

Conclusions:

Prior vaccination against selected viruses was not associated with EFS or OS among patients with lymphoma.

Impact:

We did not find evidence for an impact of prior vaccination on lymphoma prognosis.

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