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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Pachy-reticular pseudodrusen associated with pachyvitelliform maculopathy.

Enrico Romano^1,2, Vittorio Capuano¹, Serena Fragiotta³

¹Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|June 24, 2026

Summary

Pachy-reticular pseudodrusen (pachy-RPD) with pachyvitelliform maculopathy (PVM) show distinct imaging features compared to acquired vitelliform lesions. This study characterizes pachy-RPD/PVM, noting differences in lesion size and outer retinal involvement.

Keywords:

Adult-Onset Foveomacular Vitelliform Dystrophy (AOFVD)Age-related macular degeneration (AMD)Biomarker Pachy-reticular pseudodrusen (pachy-RPD)Pachychoroid Pachyvitelliform maculopathy (PVM)Reticular pseudodrusen (RPD)Subretinal drusenoid deposits (SDD)

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Area of Science:

Ophthalmology
Retinal Diseases
Medical Imaging

Background:

Pachyvitelliform maculopathy (PVM) is a rare condition.
Pachy-reticular pseudodrusen (pachy-RPD) is a specific subtype.
Understanding their distinct phenotypes is crucial for diagnosis and management.

Purpose of the Study:

To characterize the phenotype of pachy-reticular pseudodrusen (pachy-RPD) associated with pachyvitelliform maculopathy (PVM).
To compare the imaging and morphological features of pachy-RPD/PVM with acquired vitelliform lesions (AVL).

Main Methods:

Retrospective, case-control study of patients over 50 with pachy-RPD/PVM.
Acquired vitelliform lesions (AVL) served as controls.
Multimodal imaging analysis including OCT, fundus autofluorescence, OCTA, and dye-based angiography.

Main Results:

Pachy-RPD/PVM eyes had smaller lesions but more frequent external limiting membrane discontinuities and hypertransmission compared to AVL eyes.
24% of pachy-RPD/PVM cases showed late-stage complications in the fellow eye, such as neovascularization or atrophy.
Distinct imaging and morphological features were identified for pachy-RPD/PVM.

Conclusions:

Pachy-RPD and PVM represent a distinct phenotypic variant within vitelliform lesions.
Pachy-RPD/PVM exhibits unique characteristics compared to AVL.
Choroidal status, outer retina involvement, and hypertransmission are key associations.