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Updated: Jun 25, 2026
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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Pachy-reticular pseudodrusen associated with pachyvitelliform maculopathy
Enrico Romano1,2, Vittorio Capuano1, Serena Fragiotta3
1Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France.
Summary
Pachy-reticular pseudodrusen (pachy-RPD) with pachyvitelliform maculopathy (PVM) show distinct imaging features compared to acquired vitelliform lesions. This study characterizes pachy-RPD/PVM, noting differences in lesion size and outer retinal involvement.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Pachyvitelliform maculopathy (PVM) is a rare condition.
- Pachy-reticular pseudodrusen (pachy-RPD) is a specific subtype.
- Understanding their distinct phenotypes is crucial for diagnosis and management.
Purpose of the Study:
- To characterize the phenotype of pachy-reticular pseudodrusen (pachy-RPD) associated with pachyvitelliform maculopathy (PVM).
- To compare the imaging and morphological features of pachy-RPD/PVM with acquired vitelliform lesions (AVL).
Main Methods:
- Retrospective, case-control study of patients over 50 with pachy-RPD/PVM.
- Acquired vitelliform lesions (AVL) served as controls.
- Multimodal imaging analysis including OCT, fundus autofluorescence, OCTA, and dye-based angiography.
Main Results:
- Pachy-RPD/PVM eyes had smaller lesions but more frequent external limiting membrane discontinuities and hypertransmission compared to AVL eyes.
- 24% of pachy-RPD/PVM cases showed late-stage complications in the fellow eye, such as neovascularization or atrophy.
- Distinct imaging and morphological features were identified for pachy-RPD/PVM.
Conclusions:
- Pachy-RPD and PVM represent a distinct phenotypic variant within vitelliform lesions.
- Pachy-RPD/PVM exhibits unique characteristics compared to AVL.
- Choroidal status, outer retina involvement, and hypertransmission are key associations.
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