Mouse models to study von Willebrand factor in inflammation: a scoping review

Area of Science:

• Inflammation research
• Hematology
• Vascular biology

Background:

• Von Willebrand Factor (VWF) is released during vascular injury and contributes to inflammatory conditions.
• Understanding VWF's role in inflammation is critical for developing targeted treatments.

Purpose of the Study:

• To identify and evaluate mouse models used for studying von Willebrand Factor (VWF) in inflammation.
• To assess the suitability of existing models for VWF research.

Main Methods:

• A comprehensive literature search identified studies on mouse models of inflammation up to October 2024.
• Data extraction focused on model methodology, VWF/ADAMTS13 changes, and organ outcomes.

Main Results:

• 150 studies met criteria; 25% used C57BL/6 mice, 43% used only males.
• Most studies used acute (63%) or chemically induced (37%) inflammation models.
• 75% reported increased VWF antigen, 31% increased VWF activity; 33% noted ADAMTS13's therapeutic potential.

Conclusions:

• Significant variability exists in mouse models for studying VWF in inflammation.
• Future research should standardize methodologies to improve VWF-related outcome assessment and therapeutic development.