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Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Clinical Pharmacology of Plozasiran
Jessica Huston1, Dontia Orey2, Kelli Corona1
1Department of Pharmacy Education and Practice, College of Pharmacy, University of Florida, 580 W. 8th Street, Jacksonville, FL, 32209, USA.
Abstract:
Hypertriglyceridemia can increase the risk of acute pancreatitis and atherosclerotic cardiovascular disease (ASCVD). Patients with familial chylomicronemia syndrome are at an even higher risk of developing pancreatitis due to elevated triglycerides. A pathway involving small interfering RNA that selectively inhibits apolipoprotein C-III (APOC3) messenger RNA through RNA interference is currently being studied to reduce levels of apoC-III and thus, triglycerides. This review presents and discusses the current pharmacokinetic, pharmacodynamics, and clinical and scientific evidence pertaining to plozasiran, a small interfering RNA medicine.
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