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Updated: Jun 25, 2026
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Published on: February 10, 2023
Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review
Helene Marie Haug1,2, Hilde Risstad3, Rolf Eikeland Hagen4,5
1Department of Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway. b31831@ous-hf.no.
Abstract:
Single anastomosis sleeve ileal (SASI) bypass combines sleeve gastrectomy with intestinal bipartition to promote weight loss and metabolic improvement. We conducted a systematic review and meta-analysis comparing SASI with sleeve gastrectomy (1 RCT and 4 non-randomized comparative studies (NRCTs)), one-anastomosis gastric bypass (2 RCTs, 4 NRCTs), and Roux-en-Y gastric bypass (2 NRCTs), regarding weight loss, metabolic and nutritional outcomes, and adverse effects. Certainty of evidence was assessed with GRADE for 1-year outcomes. Twenty-six studies (1603 patients) were included, mostly reporting 12-month results. Pooled single-arm analysis from 11 studies showed mean total weight loss of 35.9 kg (95% CI 33.3-38.5). The certainty of evidence ranged from low to very low, limiting confidence in the results and emphasizing the need for high-quality RCTs.
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