Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab in Difficult-to-treat Chronic Spontaneous Urticaria: A Real-world Multicentre Cohort Study.

Acta dermato-venereologica·2026
Same author

Effectiveness of Botulinum Toxin Type A for Trichodynia Associated with Hair Loss Disorders: A Retrospective Study.

Dermatology and therapy·2026
Same author

The State of the Art in Chronic Prurigo Nodularis.

Dermatology and therapy·2026
Same author

Real-World Evidence That As-Needed Dosing with Bimekizumab in Patients with Psoriasis Is Safe and Effective over Time.

Journal of personalized medicine·2026
Same author

Gold-Induced Hypersensitivity Reaction After Fractional Radiofrequency Microneedling: A Case Report.

Contact dermatitis·2026
Same author

Complementary therapies for multiple sclerosis: Scoping review with evidence gap map.

Multiple sclerosis and related disorders·2026

Related Experiment Video

Updated: Jun 25, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Progression From Acute to Chronic Urticaria: A Systematic Review.

Enrique Gómez de la Fuente1, Francisco Javier Ortiz de Frutos2, Noelia Álvarez-Díaz3

  • 1Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain.

JAMA Dermatology
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

No single factor reliably predicts progression from acute urticaria (AU) to chronic urticaria (CU). Current evidence does not support aggressive acute-phase treatments solely to prevent chronicity, emphasizing clinical evaluation and follow-up.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Jun 25, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

  • Dermatology and Immunology
  • Allergy and Clinical Immunology

Background:

  • Progression from acute urticaria (AU) to chronic urticaria (CU) occurs in a subset of patients.
  • Identifying prognostic factors for AU to CU progression is challenging due to heterogeneous and uncertain evidence.

Purpose of the Study:

  • To systematically review clinical, laboratory, and treatment-related factors associated with progression from AU to CU.

Main Methods:

  • Systematic search of MEDLINE, Embase, and Web of Science for observational studies up to December 31, 2025.
  • Independent screening, data extraction, and risk of bias assessment (Newcastle-Ottawa Scale).
  • Certainty of evidence assessed using the GRADE approach; findings synthesized qualitatively due to heterogeneity.

Main Results:

  • Sixteen studies (52,564 patients) reported AU to CU progression rates from 5.8% to 36.0%.
  • Clinical factors (severity, angioedema, sensitization, atopy) and laboratory markers (IgE, eosinophils, inflammatory indices, autoantibodies) showed inconsistent associations.
  • Systemic corticosteroids in the acute phase were not linked to reduced progression risk.

Conclusions:

  • No single marker consistently predicts AU to CU progression.
  • Aggressive acute-phase treatment is not supported solely for preventing chronicity; clinical evaluation and follow-up are crucial.
  • Further well-designed, multicenter prospective studies with standardized outcomes and longer follow-up are needed.