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Published on: March 15, 2022

Dual antiplatelet therapy is an effective treatment method after coronary artery endarterectomy: a single-centre

Yalçın Günerhan1, Mehmet Işık1, Serkan Yıldırım1

  • 1Department of Cardiovascular Surgery, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye.

Cardiovascular Journal of Africa
|June 24, 2026
PubMed

Insights

Dual antiplatelet therapy (DAPT) effectively manages outcomes after coronary artery bypass grafting with endarterectomy (CABG-CE). This study evaluated early postoperative acute coronary syndrome, mortality, and morbidity in CABG-CE patients receiving DAPT.

Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Clinical Outcomes Research

Background:

  • Coronary artery bypass grafting with endarterectomy (CABG-CE) is a complex procedure.
  • Postoperative management, including dual antiplatelet therapy (DAPT), is crucial for patient outcomes.
  • Limited data exists on the early postoperative period following CABG-CE with DAPT.

Purpose of the Study:

  • To investigate the early postoperative outcomes of patients undergoing CABG-CE.
  • To assess the incidence of acute coronary syndrome, mortality, and morbidity in this cohort.
  • To evaluate the effectiveness of DAPT in the early postoperative period after CABG-CE.

Main Methods:

  • A retrospective study of 99 patients who underwent CABG-CE between 2022 and 2024.
  • Postoperative DAPT was administered to all included patients.
  • Preoperative and postoperative ECG, echocardiography (Echo), ejection fraction (EF) changes, operative time, 30-day mortality, and ICU length of stay were analyzed.

Main Results:

  • Left anterior descending (LAD) endarterectomy (38.4%) was associated with myocardial infarction (MI) in 8 patients and arrhythmia in 8 patients, with 2 mortalities.
  • Right coronary artery (RCA) endarterectomy (38.4%) showed 2 ECG changes, 9 arrhythmias, and 2 mortalities.
  • Circumflex artery (CX) endarterectomy (12.1%) resulted in 3 ECG changes, 5 arrhythmias, and 2 mortalities. Longer cross-clamping time was noted for LAD endarterectomy. Mean ICU stay was 4.0 ± 4.5 days.

Conclusions:

  • Dual antiplatelet therapy (DAPT) demonstrates effectiveness in the early postoperative period following CABG-CE.
  • DAPT is particularly beneficial for patients with diabetes mellitus (DM), diffuse, long-segment, or calcified plaques.
  • The findings support the use of DAPT to mitigate early complications after CABG-CE.
Abstract

Keywords:
Coronary endarterectomycoronary artery bypass graftingdual antiplatelet therapy

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