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Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...

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Updated: Jun 26, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

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Published on: August 4, 2018

Human donor liver viability evaluation with polarization-sensitive optical coherence tomography.

Feng Yan^1,2, Qinghao Zhang¹, Bornface M Mutembei¹

¹Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USA.

Science Translational Medicine

|June 24, 2026

Summary

Polarization-sensitive optical coherence tomography (PS-OCT) noninvasively assesses donor liver viability. This technology correlates well with pathology and transplant outcomes, potentially reducing liver discard rates.

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Last Updated: Jun 26, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

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Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation

Preservation of Porcine Donation after Circulatory Death (DCD) Liver by Perfusion and Orthotopic Liver Transplantation

Published on: June 14, 2024

Area of Science:

Medical Imaging
Transplantation Science
Biomedical Engineering

Background:

Donor liver shortage limits human liver transplantation.
Marginal livers from extended criteria donors are increasingly utilized.
Current viability assessment relies on invasive biopsy, necessitating noninvasive methods.

Purpose of the Study:

To introduce polarization-sensitive optical coherence tomography (PS-OCT) for multiparameter donor liver viability assessment.
To evaluate PS-OCT's ability to noninvasively quantify hepatic parameters across the entire liver surface.
To correlate PS-OCT findings with histopathology, ex vivo perfusion, and clinical transplant outcomes.

Main Methods:

PS-OCT imaging was performed on multiple regions of human donor livers.
Histopathological evaluations served as the gold standard for cross-validation.
Machine learning and texture analysis were employed to quantify steatosis, fibrosis, inflammation, and necrosis.

Main Results:

PS-OCT showed >80% correlation with histopathological assessments of liver steatosis, fibrosis, inflammation, and necrosis.
PS-OCT findings strongly correlated with donor liver functional performance during normothermic machine perfusion.
PS-OCT results demonstrated significant correlations with clinical liver transplant outcomes.

Conclusions:

PS-OCT offers a noninvasive, comprehensive assessment of donor liver viability.
This technique effectively complements traditional pathological analysis, potentially reducing high-risk liver discard.
PS-OCT could expand the donor pool and improve the safety of liver transplantation.