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Related Experiment Video

Updated: Jun 26, 2026

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
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Published on: June 2, 2023

Inflammatory monocytes constrain YAP-induced cell proliferation.

Serrena Singh1,2, Nareh Tahmasian3, Jia-Jun Liu4

  • 1Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Yale School of Medicine, New Haven, CT 06520, USA.

Science Advances
|June 24, 2026
PubMed
Summary

The Hippo pathway coactivators YAP and TAZ have distinct roles. YAP promotes cell dedifferentiation and immune clearance, while TAZ drives organ growth and sustained maintenance, impacting cancer patient survival.

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Published on: November 23, 2017

Area of Science:

  • Cell biology
  • Cancer research
  • Immunology

Background:

  • YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) are key transcriptional coactivators in the Hippo pathway.
  • These proteins regulate cellular growth and organ size.
  • Their distinct structures suggest unique functional roles that warrant investigation.

Purpose of the Study:

  • To investigate the independent functional differences between YAP and TAZ.
  • To analyze the long-term behavior of YAP- and TAZ-predominant clones in the liver.
  • To explore the impact of YAP and TAZ on immune responses and disease outcomes.

Main Methods:

  • Generation of YAP- and TAZ-predominant cell clones in a liver model.
  • Long-term observation of clonal behavior and organ growth.
  • Analysis of immune cell recruitment and inflammatory environment.
  • Correlation of YAP/TAZ expression with patient survival data in colorectal cancer and hepatocellular carcinoma.

Main Results:

  • YAP clones induced rapid cell dedifferentiation and inflammatory immune cell recruitment, leading to clearance.
  • TAZ clones promoted an anti-inflammatory environment, resulting in sustained organ growth and increased mortality.
  • Inhibition of inflammatory monocytes allowed YAP clonal growth.
  • High YAP expression correlated with better 5-year survival in colorectal cancer patients, while high TAZ expression correlated with poor survival.

Conclusions:

  • YAP and TAZ exhibit distinct biological functions with significant implications for organ homeostasis and disease.
  • YAP's pro-inflammatory role contrasts with TAZ's pro-growth and anti-inflammatory effects.
  • Understanding these intrinsic differences is crucial for developing targeted therapies in YAP/TAZ-driven diseases like cancer.