Related Experiment Video
Updated: Jun 26, 2026
15:07
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Beyond Static Subtypes in Large B-cell Lymphoma: Context, Plasticity, and Therapeutic Logic
Laura K Hilton1, Christopher R Flowers2, Jean L Koff3
1Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, Canada.
Blood Cancer Discovery
|June 24, 2026
Summary
Genomic classifiers offer insights into large B-cell lymphoma (LBCL) but struggle with consistent outcome prediction. Future precision medicine in LBCL requires integrated models combining genetics, biology, and patient ancestry.
Area of Science:
- Hematology
- Genomics
- Oncology
Background:
- Genomic classifiers have advanced understanding of large B-cell lymphoma (LBCL) biology.
- Current genomic classifiers have limitations in predicting patient outcomes across diverse settings.
Purpose of the Study:
- To highlight the need for integrated models in precision medicine for LBCL.
- To identify key components for future predictive models in LBCL.
Main Methods:
- Review of current genomic classification strategies in LBCL.
- Analysis of emerging evidence for integrated predictive modeling.
Main Results:
- Genomic classifiers provide biological insights but lack consistent prognostic power.
- Predictive accuracy in LBCL is limited by patient heterogeneity and therapeutic variability.
Conclusions:
- Integrated models are essential for advancing precision medicine in LBCL.
- Future models must incorporate tumor genetics, transcriptional state, microenvironment, and ancestry-informed biology.
Related Concept Videos
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:20Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
01:21Lineage Commitment
Commitment is the process whereby stem cells:
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...