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Updated: Jun 26, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Quaternary N-Heterobenzylic Carbon Centers via Allene-Mediated C-H Functionalization of Azines/Azoles:
Nicholas K Bowers1, Brandon I Gonzalez1, Niclas Müller1
1Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
None:
Metal-catalyzed N-heteroaryl C-H functionalizations to form quaternary heterobenzylic carbon centers are described. Exposure of 1,1-disubstituted allenes to the ruthenium catalyst derived from RuHCl(CO)(PPh3)3 and Cy-BIPHEP results in generation of allylruthenium nucleophiles that engage in azine or azole C═N addition to deliver transient dearomatized homoallylic amidoruthenium complexes, which upon β-hydride elimination release products bearing quaternary N-heterobenzylic carbon centers with regeneration of the starting ruthenium hydride. The dearomative addition-β-hydride elimination pathway is corroborated by deuterium-labeling experiments and interception of the dearomatized amidoruthenium intermediate through its protonolytic cleavage by 2-propanol and conversion to the methanesulfonamide. Comparison of RuCl(η3-C3H5)(CO)(Cy-BIPHEP) vs RuCl(η3-C3H5)(CO)(BIPHEP), including single crystal X-ray diffraction and IR data, provides insight into the superior performance of the Cy-BIPHEP-modified catalyst.
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