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  1. Home
  3. Precision-guided Suprachoroidal Injection Using Ultrasound Biomicroscopy And Custom-length Microneedles.
  1. Home
  3. Precision-guided Suprachoroidal Injection Using Ultrasound Biomicroscopy And Custom-length Microneedles.

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Precision-Guided Suprachoroidal Injection Using Ultrasound Biomicroscopy and Custom-Length Microneedles.

Puranjay Gupta1, Emily Kao1, William F Chadwick1

  • 1Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, Illinois.

Ophthalmic Surgery, Lasers & Imaging Retina
|June 24, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Ultrasound biomicroscopy (UBM) guided suprachoroidal (SC) injections improve accuracy by selecting needles based on scleral thickness. This method enhances first-pass success and reduces complications for posterior drug delivery.

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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Drug Delivery Systems

Background:

  • Suprachoroidal (SC) injection is key for targeted posterior drug delivery.
  • Current SC injection methods rely on subjective tactile feedback, leading to potential complications.
  • Ultrasound biomicroscopy (UBM) offers a potential solution for objective guidance.

Purpose of the Study:

  • To evaluate UBM-guided custom needle selection for improving first-pass SC injection success.
  • To assess the accuracy of SC injections using UBM guidance based on scleral thickness.

Main Methods:

  • Ten ex vivo porcine eyes were analyzed using UBM to measure scleral thickness.
  • Custom needle lengths (0.5-1.5 mm) were selected based on UBM measurements.
  • SC injections were performed under real-time UBM guidance, with confirmation of needle entry and injectate spread.

Main Results:

  • UBM confirmed successful SC injection in all tested specimens.
  • A significant increase in scleral thickness post-injection validated successful drug delivery.
  • Hypoechoic separation between the sclera and choroid was visualized by UBM.

Conclusions:

  • UBM-guided needle selection facilitates accurate SC injections.
  • This technique may reduce the incidence of failed injections and associated risks.
  • The UBM-guided approach holds promise for enhancing SC drug delivery efficacy and clinical application.