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Related Experiment Video

Updated: Jun 26, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Toxic and explosive risks in pharmacy: an underestimated reality.

Khristina Yap Larioui¹, Karim Khoukh¹, Sarah Zekri¹

¹Pharmacie Delpech Paris, Paris, France.

Presse Medicale (Paris, France : 1983)

|June 24, 2026

Summary

Pharmacists face significant risks from toxic and explosive chemicals in pharmacies. Implementing strict safety protocols, including proper storage, PPE, and training, is crucial for mitigating these hazards.

Keywords:

CMR Chemical risks explosive products potassium clavulanate preparation toxic products

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Last Updated: Jun 26, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

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Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology

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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

Published on: May 10, 2016

Area of Science:

Pharmaceutical Sciences
Occupational Health and Safety

Background:

Pharmacists handle numerous toxic and explosive substances daily.
Compounding pharmacies expose staff to hazards like carcinogenic, mutagenic, and reprotoxic (CMR) drugs.
Environmental and secondary contamination risks exist from powder dispersion and volatile vapors.

Purpose of the Study:

To highlight the underestimated risks pharmacists face from hazardous materials.
To outline the toxicological and explosive dangers present in pharmacy settings.
To emphasize the need for enhanced safety measures in pharmaceutical practice.

Main Methods:

Review of hazardous substance handling in compounding pharmacies.
Identification of risks associated with CMR substances, volatile solvents, and chemical reactions.
Analysis of current safety protocols and challenges.

Main Results:

Pharmacists are exposed to CMR substances, flammable solvents, and risks of chemical reactions.
Standard protective gear may not prevent indirect exposure to dispersed powders or vapors.
Drug shortages can increase risks by forcing the use of unfamiliar raw materials, like potassium clavulanate dust explosion risks.

Conclusions:

Strict preventive measures are essential, including fume hoods, PPE, and standardized protocols.
Proper storage of flammable substances (ATEX-compliant cabinets) and clear labeling (SDS) are critical.
A culture of vigilance, continuous education, and adherence to safety protocols are vital for pharmacist safety.