Antivirals Improve Outcomes in Influenza
Tonmoy Shanto1, Yusuf Zarhiya1, Jaclyn Dibello1
1Department of Emergency Medicine, Staten Island University Hospital Northwell, 475 Seavieew Avenue, Staten Island, NY 10305, USA.
None:
Influenza is a significant global health concern, with millions of cases, hospitalizations, and deaths annually, particularly impacting older adults and children. Antivirals like neuramidase inhibitors (oseltamivir, zanamivir, and peramivir) and endonuclease inhibitors (baloxavir) can help with treatment when started within 48 hours of symptom onset, primarily shortening illness duration by about 1 day. They should also be considered for treatment of hospitalized, severely ill, or high-risk patients (ie. elerly, pregnant and immunocompromized). However, for healthy, low-risk outpatients, the clinical benefit is modest, adn the risk of side effects is high.
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