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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
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Hormones and Bone Tissue

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Related Experiment Video

Updated: Jun 26, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Non-interruptive decision support to increase appropriate screening for primary hyperparathyroidism.

Jesse E Passman1, Jasmine Hwang1, Mika Epps2

  • 1Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA; Leonard Davis Institute, University of Pennsylvania, Philadelphia, PA, USA.

American Journal of Surgery
|June 24, 2026
PubMed
Summary
This summary is machine-generated.

New clinician alerts significantly boosted screening for primary hyperparathyroidism (PHPT). These non-interruptive tools increased testing rates and the detection of likely PHPT cases in primary care settings.

Keywords:
Behavioral economicsComputable phenotypingImplementation scienceNudgePrimary hyperparathyroidism

Related Experiment Videos

Last Updated: Jun 26, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Area of Science:

  • Endocrinology
  • Health Informatics
  • Clinical Process Improvement

Background:

  • Primary hyperparathyroidism (PHPT) affects 1% of adults, yet screening rates remain low, with fewer than one-third of eligible patients tested.
  • Current screening protocols often fail to identify at-risk individuals efficiently.

Purpose of the Study:

  • To develop and evaluate novel, non-interruptive, clinician-facing alerts designed to enhance appropriate screening for PHPT.
  • To improve the identification and testing of patients eligible for PHPT screening.

Main Methods:

  • Implemented process changes for guideline-informed patient identification using electronic phenotyping and laboratory test ordering.
  • Developed and deployed two distinct clinician-facing alerts: one integrated with health maintenance (HM) workflows and another with pended orders (PO).
  • Retrospectively validated a computable phenotype and evaluated alert effectiveness in separate primary care clinics.

Main Results:

  • Screening laboratory orders increased significantly in clinics utilizing the PO alert (81%) and HM alert (57%) compared to control clinics (19%).
  • The PO and HM alerts were associated with higher detection rates of likely PHPT (43% and 8%, respectively) versus control clinics (2%).

Conclusions:

  • Non-interruptive, clinician-facing alerts show considerable potential for substantially increasing PHPT screening rates among appropriate patient populations.
  • These alerts represent a promising strategy for improving early detection and management of PHPT.