How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

In October 2024, Parties to the United Nations Convention on Biological Diversity agreed to a new multilateral mechanism to fund biodiversity conservation through the sharing of benefits from open biodiversity data. Biological databases hosting genetic and other biological data, known as digital sequence information (DSI), are central to the implementation of the mechanism. This paper assesses the new international agreement and its implications for DSI databases. We walk through the database provisions in COP16 Decision 16/2, which include notifying users and submitters about the mechanism, improving metadata on geographical location of sample collection, and consistency with open access, as well as consideration of the FAIR, CARE, and TRUST principles. Drawing on surveys, interviews, and a workshop with biological database managers, we identify practical and scalable measures including updating terms of use, revising submission procedures, and strengthening user communication. We also propose approaches to capture and report non-monetary benefits such as capacity building, publications, interoperability, and training. These actions illustrate how DSI databases can remain open, sustainable, and globally connected while supporting benefit-sharing from the use of DSI on genetic resources.