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Updated: Jun 26, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

Utility of Relative Activity Factors to Determine Fraction Glucuronidation and Clearance of Icenticaftor in Humans

Mitesh Patel1, Sahil Shaikh2, Felix Huth3

  • 1Pharmacokinetic Sciences, Novartis Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA. mitesh.patel@novartis.com.

Pharmaceutical Research
|June 24, 2026
PubMed
Abstract

Keywords:
UDP-glucuronosyltransferasefraction glucuronidationhepaticicenticaftorrelative activity factor

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