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Published on: July 17, 2016

The evolving landscape of acute kidney injury: research directions and changes in clinical practice

Sangyub Han1, Sejoong Kim2,3,4, Keonhwa Kim5

  • 1Seoul National University College of Medicine, Republic of Korea.

Kidney Research and Clinical Practice
|June 25, 2026
PubMed

Insights

Acute kidney injury (AKI) research is advancing with new biomarkers and therapies targeting its pathways. This review highlights emerging directions in AKI research and clinical practice for improved patient outcomes.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Biomarker Research

Background:

  • Acute kidney injury (AKI) is a prevalent and severe condition requiring comprehensive management.
  • Traditional AKI care focused on post-occurrence treatment, but current practice emphasizes prevention and novel therapeutic strategies.
  • Recent AKI research has led to the approval of new biomarkers and targeted therapeutic agents.

Purpose of the Study:

  • To provide a comprehensive overview of current and emerging trends in acute kidney injury research.
  • To connect advancements in AKI research with evolving clinical practices.
  • To stimulate innovative research and clinical advancements in AKI management.

Main Methods:

  • Review of current literature on acute kidney injury definition, epidemiology, and global disparities.
  • Analysis of recent research in AKI biomarkers, therapeutics, and continuous renal replacement therapy.
  • Exploration of the role of digital healthcare, artificial intelligence, and global collaborations in AKI research.

Main Results:

  • Summarizes current understanding of AKI definition and epidemiology, including pandemic-related changes.
  • Highlights progress in AKI biomarkers, therapeutic agents targeting pathophysiological pathways, and continuous renal replacement therapy.
  • Discusses the integration of digital health, AI, and global collaborations in advancing AKI research and care.

Conclusions:

  • AKI research is rapidly evolving, shifting towards prevention and targeted therapies.
  • Integration of new biomarkers, advanced therapies, digital health, and AI is crucial for future AKI management.
  • Bridging research discoveries with clinical practice is essential to drive innovation and improve outcomes in AKI.
Keywords:
Acute kidney injuryArtificial intelligenceBiomarkersGlobal healthTherapeutics

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