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Post-Vaccination COVID-19 Infection among Health Care Workers: Description, Determinants, and Event-History Analysis
Parvathy Thampy1, Shweta Sharma2, Munna S Raj3
1State Health Systems Resource Centre Kerala, India.
Summary
Post-vaccination COVID-19 infections in healthcare workers were infrequent and mild. Risk factors included longer working hours, while older age offered protection, emphasizing continued mitigation strategies for high-exposure groups.
Area of Science:
- Epidemiology
- Infectious Diseases
- Occupational Health
Background:
- Healthcare workers (HCWs) face elevated COVID-19 exposure risks.
- Vaccination mitigates infection and severity but breakthrough cases can occur.
- Individual and occupational factors influence post-vaccination infection risk.
Purpose of the Study:
- To assess the incidence of post-vaccination COVID-19 infections among HCWs.
- To identify determinants of breakthrough infections.
- To determine the time to infection after vaccination.
Main Methods:
- Ambidirectional cohort study (September 2021-July 2022).
- Six-month follow-up post-second vaccine dose.
- Event-history analysis using Cox regression.
Main Results:
- Incidence density of 10.64 per 100 person-years.
- Higher incidence in doctors and nurses.
- Older age (>30) decreased risk (aHR=0.35); longer hours increased risk (aHR=1.28).
- All infections were mild; no hospitalizations.
Conclusions:
- Post-vaccination COVID-19 infections in HCWs are infrequent and mild.
- Occupational exposure influences risk.
- Vaccination remains protective against severe disease; continued mitigation is needed for high-risk groups.
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