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Clinical correlation between platelet parameters and coronary artery lesions in pediatric Kawasaki disease

Yujia Ji1, Xia Chen2, Lizhi Jiang3

  • 1Pediatrics, Shiyan Maternal and Child Health Hospital, Shiyan, China.

Frontiers in Pediatrics
|June 25, 2026
PubMed

Insights

Children with Kawasaki disease (KD) show elevated platelet levels, including platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT). These elevated platelet parameters are significantly associated with the development of coronary artery lesions in KD patients.

Area of Science:

  • Pediatrics
  • Cardiology
  • Hematology

Background:

  • Kawasaki disease (KD) is a leading cause of acquired heart disease in children.
  • Coronary artery lesions (CAL) are a serious complication of KD.
  • The role of platelet parameters in the pathogenesis of CAL in KD requires further elucidation.

Purpose of the Study:

  • To investigate the clinical correlation between coronary artery lesions and platelet levels in children diagnosed with Kawasaki disease.
  • To compare platelet parameters between KD patients and healthy controls.
  • To assess the association between specific platelet indices and the presence of CAL in KD.

Main Methods:

  • Propensity score matching was employed to compare platelet parameters (platelet count [PLT], mean platelet volume [MPV], plateletcrit [PCT], and platelet distribution width [PDW]) between KD children and healthy controls.
  • KD patients were stratified into groups based on the presence or absence of coronary artery lesions.
  • The Harada score was calculated, and multiple linear regression analysis was performed to evaluate risk and correlations.

Main Results:

  • Platelet parameters (PLT, MPV, PCT, PDW) were significantly higher in KD patients compared to healthy controls.
  • KD patients with coronary artery lesions exhibited significantly higher platelet parameters than those without lesions.
  • A higher Harada score was observed in the lesion group, and multivariate analysis confirmed significant correlations between PLT, MPV, PCT, PDW, and coronary artery lesions.

Conclusions:

  • The occurrence of coronary artery lesions in children with Kawasaki disease is closely associated with elevated platelet levels.
  • Platelet parameters serve as potential indicators associated with coronary artery lesions in KD.
  • Further prospective studies are warranted to validate the clinical utility of these platelet parameters in risk stratification and management of KD.
Abstract

Keywords:
Kawasaki diseasecoronary artery lesionscorrelationplateletpropensity score matching

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