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Asymmetric Cavovarus Deformity Presentation in Charcot-Marie-Tooth Disease
Melissa R Requist1, Andrew C Peterson1, Bopha Chrea2
1Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA.
Foot & Ankle Orthopaedics
|June 25, 2026
Summary
Foot deformities in Charcot-Marie-Tooth disease (CMT) show significant differences between limbs. This asymmetry in cavovarus foot deformity highlights the need for limb-specific assessments in clinical practice and research.
Area of Science:
- Orthopedics
- Neurology
- Medical Imaging
Background:
- Charcot-Marie-Tooth disease (CMT) characteristically presents with cavovarus foot deformity, which varies significantly among individuals.
- Previous studies have focused on foot morphology but not limb symmetry, impacting functional assessments and surgical planning.
Purpose of the Study:
- To quantitatively assess limb symmetry in cavovarus foot deformity in individuals with CMT using weight-bearing computed tomography (WBCT).
- To compare deformity between paired limbs and inform functional assessment scales and surgical treatment strategies.
Main Methods:
- Bilateral WBCT images from 31 CMT patients were analyzed.
- Radiographic measurements and a statistical shape model (SSM) were generated and compared between limbs.
- Principal component analysis (PCA) described morphologic variation, with differences analyzed statistically.
Main Results:
- Significant absolute differences were found between paired limbs for all radiographic measures and SSM variations.
- Hindfoot varus rotation showed a greater magnitude of difference between limbs compared to arch height.
- No significant laterality-dependent morphologic differences were identified.
Conclusions:
- WBCT and SSM analyses confirm statistically significant limb-to-limb asymmetry in CMT-related cavovarus foot deformity.
- These findings underscore the importance of limb-specific evaluations in functional outcome measures and surgical planning for CMT patients.
- Further research is needed to quantify clinically significant differences and incorporate limb asymmetry into CMT research and patient education.
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