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Algorithm for Surgical Management of Symptomatic Hand and Digital Neuromas
Maximilian Mayrhofer-Schmid1,2,3, Niek J Nieuwdorp2,4, Devin J Clegg1
1From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Plastic and Reconstructive Surgery. Global Open
|June 25, 2026
Summary
This study offers a practical, anatomy-driven algorithm for surgical treatment of hand neuromas. It guides surgeons on choosing between reconstructive and nerve-end management techniques for better patient outcomes.
Area of Science:
- Hand surgery
- Peripheral nerve injury
- Neuroma treatment
Background:
- Symptomatic neuromas in the hand cause significant pain and functional loss.
- Surgical options for neuromas have evolved from passive to active techniques.
- A clear guide for selecting surgical approaches for hand neuromas is lacking.
Purpose of the Study:
- To develop a pragmatic, anatomy-driven algorithm for surgical decision-making in hand neuroma treatment.
- To integrate findings from a scoping review with established peripheral nerve surgery principles.
- To provide a clear overview of surgical options for symptomatic neuromas distal to the wrist.
Main Methods:
- Conducted a scoping review of surgical treatments for symptomatic neuromas distal to the wrist.
- Integrated review findings with established peripheral nerve surgery principles.
- Developed an anatomy-driven treatment algorithm to guide operative decisions.
Main Results:
- Literature on neuroma surgery is largely retrospective with varied techniques and outcomes.
- Many patients experience pain improvement after surgery, but direct technique comparisons are limited.
- The algorithm prioritizes reconstruction (primary repair or interposition) when feasible; otherwise, it details nerve-end management options.
Conclusions:
- A structured approach can streamline the evaluation and treatment selection for hand neuromas.
- The proposed algorithm offers a reproducible pathway for contemporary surgical management.
- This framework supports practical considerations for managing hand and digital neuromas.

