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Related Experiment Video

Updated: Jun 26, 2026

Sequencing of mRNA from Whole Blood using Nanopore Sequencing
11:26

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Orthogonal nanopores cross-validation for multiplex single-molecule profiling.

Lin-Lin Zhang1, Fan Gao1, Yi-He Wei1

  • 1Molecular Sensing and Imaging Center, School of Chemistry, Nanjing University Nanjing 210023 P. R. China yilunying@nju.edu.cn.

Chemical Science
|June 25, 2026
PubMed
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This summary is machine-generated.

A new nanopore multiplex sensor (NMS) enables simultaneous detection of diverse biomolecules for precision health. This breakthrough advances multiomics analysis for complex diseases like lung cancer.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Diagnostics

Background:

  • Multiplex biomolecule profiling is crucial for precision health.
  • Analyzing diverse biomolecules (DNA, RNA, peptides, etc.) simultaneously is challenging due to their varied properties.

Purpose of the Study:

  • To develop a novel nanopore multiplex sensor (NMS) for concurrent profiling of multiple biomolecule types.
  • To establish a robust and generalizable platform for rapid, parallel biomarker sensing.

Main Methods:

  • Utilized a bioelectronic microchip integrated with orthogonal nanopores.
  • Employed complementary recognition abilities of nanopores for simultaneous detection.
  • Cross-validated the sensor using five major biomolecule types relevant to non-small-cell lung cancer.

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Published on: July 6, 2022

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Last Updated: Jun 26, 2026

Sequencing of mRNA from Whole Blood using Nanopore Sequencing
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Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Main Results:

  • Achieved concurrent profiling of multiple biomolecule types in a single experiment.
  • Demonstrated simultaneous detection and relative quantification of five major biomolecule classes.
  • Validated the NMS platform's capability for biomarker sensing.

Conclusions:

  • The NMS platform overcomes previous limitations in simultaneous multi-analyte detection.
  • This technology represents a significant advancement toward single-molecule multiomics.
  • The sensor offers a generalizable approach for rapid biomarker discovery and diagnostics.