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Endoscopic papillectomy for ampullary tumors: Multicenter retrospective study
Katarzyna Połomska1, Nastazja D Pilonis2,1,3, Mateusz Szmit2,3
1Department of Surgical Oncology, Transplant Surgery and General SurgeryMedical University of GdanskGdanskPoland.
Endoscopy International Open
|June 25, 2026
Summary
Endoscopic papillectomy for ampullary tumors is effective, but larger tumors and piecemeal resection increase recurrence risk. Optimizing techniques for en bloc resection is crucial for better outcomes.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
Background:
- Endoscopic papillectomy is a minimally invasive treatment for ampullary tumors.
- Technical aspects and recurrence factors require further definition.
Purpose of the Study:
- Identify factors associated with piecemeal resection.
- Determine factors influencing recurrence-free survival after endoscopic papillectomy.
Main Methods:
- Multicenter retrospective analysis of 192 patients undergoing endoscopic papillectomy (2011-2023).
- Utilized multivariable logistic and Cox regression models.
- Median follow-up of 12 months for recurrence analysis.
Main Results:
- Adverse events occurred in 26.6% (bleeding 17.3%, pancreatitis 15.6%).
- En bloc resection achieved in 66.1%.
- Larger tumor size and submucosal injection correlated with piecemeal resection. Tumor size and piecemeal resection independently predicted shorter recurrence-free survival (40.8% recurrence).
Conclusions:
- Larger tumors and piecemeal resection are linked to increased recurrence after endoscopic papillectomy.
- Improving en bloc resection rates through technical optimization is key to reducing recurrence.
