Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

A Critical Perspective on the Role of Thirdhand Smoke in Tumorigenesis: Initiator or Promoter.

Environment & health (Washington, D.C.)·2026
Same author

Ultrafine particles and blood pressure in COPD: an underappreciated cardiovascular threat.

Thorax·2026
Same author

Modified letrozole vs GnRH antagonist protocols in ovarian aging women for IVF: an open-label, multicenter, randomized controlled trial.

Nature communications·2026
Same author

Serum Element-Driven Gut Microbial Disturbances and Their Predictive Implications for Gestational Dyslipidemia: A Prospective Birth Cohort Study.

Environmental science & technology·2026
Same author

Population-Level Amplicon and Metagenomic Analyses Uncover Distinct Effects of Landscape-Level Pesticides on the Maternal Gut Microbiome.

Environment & health (Washington, D.C.)·2026
Same author

Prenatal exposure to organochlorine pesticides and early childhood neurodevelopment: A prospective birth cohort study.

Ecotoxicology and environmental safety·2026
Same journal

The Association between Prenatal Quaternary Ammonium Compounds (QACs) Exposure and Neonatal Birth Obesity: Insights from Epidemiology and <i>In Vitro</i> Evidence.

Environment & health (Washington, D.C.)·2026
Same journal

Carboxyl Surface Modification Attenuates Polystyrene- but Not Poly(methyl methacrylate) Nanoplastic-Induced Gut Dysbiosis in Zebrafish Larvae.

Environment & health (Washington, D.C.)·2026
Same journal

Gestational Arsenic Exposure Induces Metabolic Dysfunction-Associated Fatty Liver Disease-like Phenotypes in Middle-Aged Offspring.

Environment & health (Washington, D.C.)·2026
Same journal

Exploring Toxicological Mechanisms of Typical PFAS-Induced NAFLD through Integrated Computational Toxicology and AOP Frameworks.

Environment & health (Washington, D.C.)·2026
Same journal

AI-Enabled Mapping of Structure-Hazard Relationships for Emerging Contaminants.

Environment & health (Washington, D.C.)·2026
See all related articles
  1. Home
  3. Risk Assessment Of Pfas-induced Male Reproductive Toxicity: A Comprehensive Evaluation Using The Traec Strategy.
  1. Home
  3. Risk Assessment Of Pfas-induced Male Reproductive Toxicity: A Comprehensive Evaluation Using The Traec Strategy.

Related Experiment Video

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
09:04

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Risk Assessment of PFAS-Induced Male Reproductive Toxicity: A Comprehensive Evaluation Using the TRAEC Strategy.

Xiaoyu Xu1,2, Ziye Xia1,2, Junyao Luo1,2

  • 1Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Environment & Health (Washington, D.C.)
|June 25, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Per- and polyfluoroalkyl substances (PFAS) pose a moderate risk to male fertility, with perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA) showing the highest risks for sperm abnormalities and motility issues.

Keywords:
PFASmale reproductive healthrisk assessmentsex steroid hormone levelssperm quality

More Related Videos

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
07:06

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Related Experiment Videos

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
09:04

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
07:06

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

Area of Science:

  • Environmental Health
  • Reproductive Toxicology
  • Chemical Risk Assessment

Background:

  • Male fertility has declined globally, coinciding with increased environmental chemical exposures.
  • Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants linked to male reproductive toxicity.
  • Comparative risks of individual PFAS on male reproductive health remain unclear.

Purpose of the Study:

  • To systematically assess the effects of multiple PFAS on semen quality and sex hormone levels in men.
  • To identify specific PFAS compounds posing the highest risks to male reproductive health.
  • To evaluate the overall risk level of PFAS exposure to male fertility.

Main Methods:

  • Employed the Targeted Risk Assessment of Environmental Chemicals (TRAEC) strategy for systematic review.
  • Integrated evidence from 25 epidemiological studies, 75 in vivo, and 43 in vitro experiments.
  • Conducted independent in vivo experiments to validate findings on PFNA effects.

    • Main Results:

    • PFAS exposure presents a moderate risk (score: 6.47) to male reproductive health.
    • Perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA) showed the highest risk for sperm abnormalities (scores: 7.43 and 6.38, respectively).
    • PFAS exposure poses a high risk to sperm progressive motility, particularly PFOS and PFNA.

    Conclusions:

    • PFOS and PFNA are identified as particularly detrimental to male reproductive health.
    • Urgent measures are needed to reduce PFAS exposure and mitigate risks to male fertility.
    • The study highlights the significant impact of environmental chemicals on male reproductive outcomes.