The selection of matching donors for patients in fecal microbiota transplantation

Fecal microbiota transplantation (FMT) is an emerging therapeutic strategy with potential applications in the treatment of various diseases, particularly those associated with gut microbiome dysbiosis. However, clinical trials have demonstrated considerable variability in FMT efficacy-even among patients with the same disease. The heterogeneity of gut microbiota from donors is considered a key factor influencing patient outcomes. Consequently, the development of donor-recipient matching models has emerged as an advanced approach to enhance the effectiveness of FMT. As a practical clinical intervention, the therapeutic impact of FMT on specific diseases requires further investigation. This article reviews the development of donors and the matching patterns between donors and recipients, and summarizes the key factors influencing the transfer of the microbiota. It provides new insights for exploring novel and effective donor-recipient matching patterns.