Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumour-macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR-194-5p promotes NSCLC progression.

Clinical and translational medicine·2026
Same author

Association between oral frailty and physical frailty among older adults: a meta-analysis.

BMC oral health·2026
Same author

METTL5 deficiency impairs osteogenesis through OSER1-dependent antioxidant regulation.

JCI insight·2026
Same author

YTHDC1 recognizes METTL16-dependent m<sup>6</sup>A on caRNAs and coordinates cotranscriptional splicing.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Applications of Plant Lectins in Detection and Targeted Therapy of Urological Cancers.

Drug design, development and therapy·2026
Same author

The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts.

PLoS biology·2026

Related Experiment Video

Updated: Jun 26, 2026

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment.

Qiwen Li1, Yating Sun2, Shuibin Lin3,4

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China.

Medcomm
|June 25, 2026
PubMed
Summary

RNA modifications regulate gene expression and impact cancer progression within the tumor microenvironment (TME). Targeting these RNA modifications offers a promising strategy to overcome cancer resistance and improve treatment outcomes.

Keywords:
RNA metabolismRNA modificationsimmune cellstumor microenvironment

Related Experiment Videos

Last Updated: Jun 26, 2026

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • RNA modifications are crucial regulators of gene expression in physiological and pathological conditions, especially in cancer.
  • These modifications play significant roles in the tumor microenvironment (TME), influencing tumor growth, immune evasion, and therapeutic resistance.

Purpose of the Study:

  • To provide a comprehensive overview of the mechanisms and functional roles of major RNA modifications (adenosine, guanosine, pseudouridine).
  • To discuss the regulatory roles of RNA modifications in RNA metabolism, genome integrity, and TME pathways.
  • To highlight therapeutic strategies targeting RNA-modifying enzymes for cancer treatment.

Main Methods:

  • Review of current literature on RNA modifications and their functions in cancer.
  • Analysis of the roles of RNA modifications in RNA metabolism, genome integrity, and TME-associated pathways.
  • Examination of therapeutic strategies targeting RNA-modifying enzymes.

Main Results:

  • RNA modifications significantly impact tumor growth, immune evasion, and therapeutic resistance within the TME.
  • These modifications modulate crucial stromal pathways including immune responses, extracellular matrix remodeling, and vascular supply.
  • RNA modifications dynamically regulate intercellular communication within the TME.

Conclusions:

  • Targeting RNA modifications is a promising strategy for overcoming cancer resistance.
  • Understanding RNA modification mechanisms can lead to improved cancer treatment outcomes.
  • Further research into RNA-modifying enzymes and their targeted inhibition holds potential for novel cancer therapies.