Related Experiment Video
Updated: Jun 26, 2026
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
[Ten clinical questions about recurrent or incessant pericarditis]
Massimo Imazio1, Mariacristina Tomat1, Francesco Venturelli1
1Dipartimento di Medicina, Università degli Studi di Udine e Dipartimento Cardiotoracico, Ospedale Universitario Santa Maria della Misericordia, ASUFC, Udine.
Giornale Italiano Di Cardiologia (2006)
|June 25, 2026
Summary
Recurrent pericarditis, a challenging complication of acute pericarditis, requires specific diagnosis and treatment. New therapies like interleukin-1 inhibitors offer improved outcomes for refractory cases.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Recurrent pericarditis significantly impacts quality of life.
- It is defined by new episodes after remission, distinct from incessant forms.
- Causes range from idiopathic to secondary to systemic diseases or procedures.
Purpose of the Study:
- To provide clinical guidance on managing recurrent pericarditis.
- To translate current guideline recommendations into clinical practice.
Main Methods:
- Diagnosis relies on acute pericarditis criteria, biomarkers, and imaging.
- First-line treatment includes NSAIDs/aspirin with colchicine and activity restriction.
- Corticosteroids are for selected cases; IL-1 inhibitors for refractory/steroid-dependent inflammatory forms.
Main Results:
- Interleukin-1 inhibitors have revolutionized management in inflammatory phenotypes.
- Prognosis is generally favorable in idiopathic recurrent pericarditis.
- Personalized therapeutic strategies and structured follow-up are essential.
Conclusions:
- Effective management of recurrent pericarditis involves tailored treatment strategies.
- Early recognition and appropriate therapy, including novel agents, improve patient outcomes.
- Adherence to guidelines ensures optimal care for recurrent pericarditis patients.
Related Concept Videos
01:19Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
01:22Pericarditis I: Introduction
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
01:17Pericarditis III: Medical Management
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
01:25Pericarditis IV: Nursing Management
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...