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Gut Microbiota Modulation via Synbiotics: A Perspective for Boosting Antitumor Immunity and Inactivating Carcinogens
Nurul Cholifah Lutfiana1, Adilla Shafryantyo Purnomo2, Azzahra Syadza Nasywantya Purnomo3
1Department of Biomedicine and Biochemistry, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia.
Asian Pacific Journal of Cancer Prevention : APJCP
|June 25, 2026
Summary
Synbiotics, a mix of probiotics and prebiotics, enhance children's immunity and may prevent cancer. They boost immunoglobulin G (IgG) and Natural Killer (NK) cell activity, crucial for fighting infections and reducing cancer risk.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Children's immature immune systems increase susceptibility to infections and long-term health risks.
- Early immune development, including T and B memory cells, is vital for pathogen defense and cancer prevention.
- Synbiotics (probiotics + prebiotics) modulate the gut microbiota for immune enhancement.
Purpose of the Study:
- To propose synbiotics as a strategy for dual benefits: immediate immune enhancement and potential chemoprevention.
- To explore the mechanisms by which synbiotics impact immune function and cancer risk.
- To summarize evidence supporting synbiotics for immune boosting and early cancer prevention.
Main Methods:
- This article is an opinion piece synthesizing clinical and preclinical findings.
- It proposes a mechanistic link between synbiotics, gut microbiota modulation, and immune responses.
- Focuses on the proposed dual benefits of synbiotics.
Main Results:
- Synbiotics promote beneficial gut bacteria (Lactobacillus, Bifidobacterium), increasing immunoglobulin G (IgG) production.
- Synbiotics help inactivate carcinogens and reduce harmful metabolites.
- Synbiotics enhance Natural Killer (NK) cell activity and antioxidant capacity, aiding tumor surveillance and reducing oxidative stress.
Conclusions:
- Synbiotics offer a comprehensive approach to boosting immunity in children.
- Synbiotic supplementation shows potential as an early cancer prevention strategy.
- Modulating gut microbiota with synbiotics strengthens defenses against infections and mutagenic agents.
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