Related Experiment Video

Updated: Jun 26, 2026

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells
11:00

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells

Published on: October 17, 2025

Gut Microbiota Modulation via Synbiotics: A Perspective for Boosting Antitumor Immunity and Inactivating Carcinogens

Nurul Cholifah Lutfiana1, Adilla Shafryantyo Purnomo2, Azzahra Syadza Nasywantya Purnomo3

  • 1Department of Biomedicine and Biochemistry, Universitas Muhammadiyah Surabaya, Surabaya, Indonesia.

Asian Pacific Journal of Cancer Prevention : APJCP
|June 25, 2026
PubMed

Insights

Synbiotics, a mix of probiotics and prebiotics, enhance children's immunity and may prevent cancer. They boost immunoglobulin G (IgG) and Natural Killer (NK) cell activity, crucial for fighting infections and reducing cancer risk.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Children's immature immune systems increase susceptibility to infections and long-term health risks.
  • Early immune development, including T and B memory cells, is vital for pathogen defense and cancer prevention.
  • Synbiotics (probiotics + prebiotics) modulate the gut microbiota for immune enhancement.

Purpose of the Study:

  • To propose synbiotics as a strategy for dual benefits: immediate immune enhancement and potential chemoprevention.
  • To explore the mechanisms by which synbiotics impact immune function and cancer risk.
  • To summarize evidence supporting synbiotics for immune boosting and early cancer prevention.

Main Methods:

  • This article is an opinion piece synthesizing clinical and preclinical findings.
  • It proposes a mechanistic link between synbiotics, gut microbiota modulation, and immune responses.
  • Focuses on the proposed dual benefits of synbiotics.

Main Results:

  • Synbiotics promote beneficial gut bacteria (Lactobacillus, Bifidobacterium), increasing immunoglobulin G (IgG) production.
  • Synbiotics help inactivate carcinogens and reduce harmful metabolites.
  • Synbiotics enhance Natural Killer (NK) cell activity and antioxidant capacity, aiding tumor surveillance and reducing oxidative stress.

Conclusions:

  • Synbiotics offer a comprehensive approach to boosting immunity in children.
  • Synbiotic supplementation shows potential as an early cancer prevention strategy.
  • Modulating gut microbiota with synbiotics strengthens defenses against infections and mutagenic agents.
Abstract

Keywords:
Cancer PreventionGut Microbiota ModulationImmune BoosterProbioticSynbiotic

More Related Videos

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...