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Comment on "Three-Principal-Substrate SERS Profiling Enables Reliable Screening of Serum Biomarkers: A General
1Department of Engineering and Architecture, University of Trieste, Trieste 34127, Italy.
Analytical Chemistry
|June 25, 2026
Summary
Serum SERS spectra interpretation requires careful validation. Our findings indicate purine metabolites, not proteins, dominate these spectra, challenging previous assignments and ensuring reliable diagnostics.
Area of Science:
- Analytical Chemistry
- Biochemistry
- Spectroscopy
Background:
- Conventional band assignments are used to interpret serum Surface-Enhanced Raman Spectroscopy (SERS) spectra.
- Previous studies suggest serum SERS spectra are influenced by proteins and lipids.
