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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...

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Related Experiment Video

Updated: Jun 26, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

REG3A: A Potential Fecal Biomarker for Ulcerative Colitis.

Xinrui Lv1, Yaxin Qi1, Jia Guo1

  • 1Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China, tjmugh.com.cn.

Mediators of Inflammation
|June 25, 2026
PubMed
Summary
This summary is machine-generated.

Fecal regenerating islet-derived protein 3-alpha (REG3A) levels correlate with ulcerative colitis (UC) severity. Combining REG3A with fecal calprotectin (FC) improves UC disease activity assessment.

Keywords:
fecal calprotectinregenerating islet-derived protein 3-alphaulcerative colitis

Related Experiment Videos

Last Updated: Jun 26, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Area of Science:

  • Gastroenterology
  • Immunology
  • Biomarker Discovery

Background:

  • Regenerating islet-derived protein 3-alpha (REG3A) is an antimicrobial peptide involved in intestinal mucosal repair.
  • Its role as a biomarker for inflammatory bowel disease, specifically ulcerative colitis (UC), requires further investigation.

Purpose of the Study:

  • To evaluate fecal REG3A as a biomarker for assessing disease activity in ulcerative colitis (UC).
  • To compare the diagnostic performance of REG3A against fecal calprotectin (FC) and a combined model.

Main Methods:

  • A prospective cohort study included 82 UC patients and 20 controls.
  • Fecal REG3A and FC levels were measured and analyzed using receiver operating characteristic (ROC) analysis.
  • Immunohistochemistry was used to assess REG3A expression in intestinal biopsies.

Main Results:

  • Fecal REG3A levels increased significantly with UC clinical severity (p < 0.001).
  • A combined model of REG3A and FC demonstrated superior performance in differentiating UC disease activity compared to individual biomarkers.
  • REG3A expression was confirmed in active UC colonic tissues.

Conclusions:

  • Fecal REG3A is a promising biomarker for assessing UC disease activity.
  • Combining REG3A with FC enhances the accuracy of predicting clinical severity in UC patients.